Friday, June 05, 2020
Profile

Dr. Hazrat Ali

alibiotechnologist@gmail.com


Senior Scientist


Work Phone: +92-41-9201316 to 20 Ext: 239
Dr. Hazrat Ali

RESEARCH INTEREST:

  • Combinatorial strategies for enhance production of industrially important enzymes
  • Identification and Characterization of Genes/Pathways encoding Non Ribosomal Peptide Synthetase and Polyketide Synthetase in Fungi and Bacteria.
  • Development of advance biotechnological techniques for domain/module exchange in a Non Ribosomal Peptides Synthetase.
  • Development of a fungal species as a model organism.
  • Identification, characterization and conservation of fungal strains in Pakistan.

 

Academic Qualifications:

Degree

University

Subjects

Year

Post Doc.

University of Groningen.

Biotechnology (Molecular Microbiology)

20012-20014

Ph. D

University of Groningen

Biotechnology (Molecular Microbiology)

2012

B. S (Hons)

University of Malakand

Biotechnology

2005

F. Sc.

B.I.S.E., Peshawar.

(Islamia College, Peshawar).

Pre-medical

2001

 

Publications List:

  1. Hazrat Ali and Arnold Driessen., (2013) “Non robisomal Peptide synthetase and secondary metabolites production in Penicillium chrysogenum” ISBN: 978-903676556-5.  Bibliotheek, RuG, Groningen
  2. Hazrat Ali, Marco Ries, Jeroen.G. Nijland, Peter Lankhorst, Thomas Hankemeier, Roel A.L. Bovenberg, Rob J. Vreeken, Arnold J.M. Driessen. A branched biosynthetic pathway is involved in production of roquefortine and related compounds in Penicillium chrysogenum. PLoS ONE 8(6): e65328. doi:10.1371/journal.pone.0065328.
  3. Hazrat Ali, Marco Ries, Jeroen.G. Nijland, Peter Lankhorst, Thomas Hankemeier, Roel A.L. Bovenberg, Rob J. Vreeken, Arnold J.M. Driessen.  Novel key metabolites reveal further branching of the roquefortine/meleagrin biosynthetic pathway. Journal of Biological chemistry doi: 10.1074/jbc.M113.512665
  4. Hazrat Ali, Marco Ries, Jeroen.G. Nijland, Peter Lankhorst, Thomas Hankemeier, Roel A.L. Bovenberg, Rob J. Vreeken, Arnold J.M. Driessen.  A non-canonical NRPS is involved in the synthesis of fungisporin and related hydrophobic cyclic tetrapeptides in Penicillium chrysogenum. PLoS One. 2014 Jun 2;9(6):e98212. doi: 10.1371/journal.pone.0098212.
  5. Ouchaou K, Maire F, Salo O, Hazrat Ali, Hankemeier T, van der Marel GA, Filippov DV, Bovenberg RA, Vreeken RJ, Driessen AJ, Overkleeft HS. A mutasynthesis approach with a Penicillium chrysogenum ΔroqA strain yields new roquefortine D analogues. Chembiochem. 2015 Apr 13;16(6):915-23. doi: 10.1002/cbic.201402686. Epub 2015 Mar 12
  6. Hazrat Ali, Zahir Ali, Haidar Ali,Sultan Mehmood and Wiqar Ali. In vitro regeneration of brassica napus l., Cultivars (star, cyclone and westar) from Hypocotyls and cotyledonary leavesPakistan Journal of Botany. 39(4): 1251-1256, 2007.  
  7. Marco Ries, Hazrat Ali, Arnold Driessen, Thomas Hankemeier, T Reijmers, Rob Vreeken.,  Multiple stage fragmentation tree comparison enables detailed structure elucidation in direct infusion mass spectrometry based experiments. Genomics driven metabolomics, 113:
  8. Marco Ries, Hazrat Ali, Arnold Driessen, Thomas Hankemeier, T Reijmers, Rob Vreeken., Chemoinformatics supported MSn Comparison Pipeline (CMCP): Towards automated de novo structure elucidation using multiple-stage fragmentation tree comparison Genomics driven metabolomics, 98: 



   
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